Impact of genetic analysis on Parkinson's disease research
Identifieur interne : 004068 ( Main/Exploration ); précédent : 004067; suivant : 004069Impact of genetic analysis on Parkinson's disease research
Auteurs : John Hardy [États-Unis, Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 2003-09.
Descripteurs français
- Pascal (Inist)
- Wicri :
English descriptors
- KwdEn :
- Cysteine Endopeptidases (genetics), DNA Mutational Analysis, Genetic Predisposition to Disease (genetics), Genetics, Human, Humans, Intracellular Signaling Peptides and Proteins, Multienzyme Complexes (genetics), Nerve Tissue Proteins (genetics), Oncogene Proteins (genetics), Parkinson Disease (diagnosis), Parkinson Disease (genetics), Parkinson disease, Parkinson's disease, Pathophysiology, Proteasome Endopeptidase Complex, Review, Synuclein, Synucleins, Ubiquitin, Ubiquitin (genetics), Ubiquitin-Protein Ligases (genetics), genetics, parkin, proteasone, synuclein, ubiquitin hydrolase.
- MESH :
- chemical , genetics : Cysteine Endopeptidases, Multienzyme Complexes, Nerve Tissue Proteins, Oncogene Proteins, Ubiquitin, Ubiquitin-Protein Ligases.
- diagnosis : Parkinson Disease.
- genetics : Genetic Predisposition to Disease, Parkinson Disease.
- DNA Mutational Analysis, Humans, Intracellular Signaling Peptides and Proteins, Proteasome Endopeptidase Complex, Synucleins.
Abstract
Genetic analysis is changing our view of Parkinson's disease: not only is it challenging the long‐cherished views about the diagnosis of the disease, it is also starting to suggest a biochemical pathway to disease pathogenesis. These developments are reviewed in the context of three known (synuclein, parkin, and DJ‐1) and one suspected (ubiquitin hydrolase) genes for the disease. © 2003 Movement Disorder Society
Url:
DOI: 10.1002/mds.10569
Affiliations:
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Le document en format XML
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2003-09">2003-09</date><biblScope unit="vol">18</biblScope><biblScope unit="issue">S6</biblScope><biblScope unit="supplement">6</biblScope><biblScope unit="page" from="96">96</biblScope><biblScope unit="page" to="98">98</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">55C2C4B088F05B8D9AC725A58F7ED2B60DAC35A6</idno><idno type="DOI">10.1002/mds.10569</idno><idno type="ArticleID">MDS10569</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cysteine Endopeptidases (genetics)</term><term>DNA Mutational Analysis</term><term>Genetic Predisposition to Disease (genetics)</term><term>Genetics</term><term>Human</term><term>Humans</term><term>Intracellular Signaling Peptides and Proteins</term><term>Multienzyme Complexes (genetics)</term><term>Nerve Tissue Proteins (genetics)</term><term>Oncogene Proteins (genetics)</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (genetics)</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Pathophysiology</term><term>Proteasome Endopeptidase Complex</term><term>Review</term><term>Synuclein</term><term>Synucleins</term><term>Ubiquitin</term><term>Ubiquitin (genetics)</term><term>Ubiquitin-Protein Ligases (genetics)</term><term>genetics</term><term>parkin</term><term>proteasone</term><term>synuclein</term><term>ubiquitin hydrolase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Cysteine Endopeptidases</term><term>Multienzyme Complexes</term><term>Nerve Tissue Proteins</term><term>Oncogene Proteins</term><term>Ubiquitin</term><term>Ubiquitin-Protein Ligases</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Genetic Predisposition to Disease</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>DNA Mutational Analysis</term><term>Humans</term><term>Intracellular Signaling Peptides and Proteins</term><term>Proteasome Endopeptidase Complex</term><term>Synucleins</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Article synthèse</term><term>Génétique</term><term>Homme</term><term>Parkine</term><term>Parkinson maladie</term><term>Physiopathologie</term><term>Ubiquitine</term><term>α-Synucléine</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Génétique</term><term>Homme</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Genetic analysis is changing our view of Parkinson's disease: not only is it challenging the long‐cherished views about the diagnosis of the disease, it is also starting to suggest a biochemical pathway to disease pathogenesis. These developments are reviewed in the context of three known (synuclein, parkin, and DJ‐1) and one suspected (ubiquitin hydrolase) genes for the disease. © 2003 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Maryland</li></region><settlement><li>Londres</li></settlement></list><tree><country name="États-Unis"><region name="Maryland"><name sortKey="Hardy, John" sort="Hardy, John" uniqKey="Hardy J" first="John" last="Hardy">John Hardy</name></region></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Hardy, John" sort="Hardy, John" uniqKey="Hardy J" first="John" last="Hardy">John Hardy</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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